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Academics | Research | Faculty | Administration

Division of Gynecologic Oncology Research

The Division of Gynecologic Oncology participates in a diverse array of research activities. We have world-renowned researchers who participate in the development of novel drugs and targeted therapies for all types of gynecologic cancers through phase 1, 2 and 3 clinical trials.

Our research portfolio includes the study of molecular profiling of gynecologic cancers to enhance the practice of personalized medicine and once-imaging techniques to more accurately detect tumors invisible to the naked eye or conventional radiographic studies.

In addition, we have a vibrant program in health services and outcomes research for women with gynecologic cancer that includes the study of quality of care metrics and combating cancer health disparities. We welcome the opportunity to collaborate with like-minded researchers from around the world to advance the science of gynecologic cancer in a meaningful and applicable way. 

Team of specialists

As interim director of the UC Irvine School of Medicine Gynecologic Oncology Division, Dr. Krishnansu Tewari  has assembled a distinguished team of specialists conducting clinical trials to find promising cervical and ovarian cancer drugs and develop less invasive surgical procedures. Partly because of the contributions of his group, UC Irvine Medical Center has been consistently named one of U.S. News & World Report's 50 best hospitals in the country for gynecology services.

The Division of Gynecologic Oncology is one of the most active research programs at the UC Irvine Health Chao Family Comprehensive Cancer Center and nationally. The purpose of this program is to conduct basic and clinical studies of gynecologic premalignancies and malignancies and to use this knowledge to improve the care of patients with these diseases. The division also manages one of a few only National Cancer Institute(NCI)-funded fellowship training grants in the nation for gynecologic oncology.

Since 1993, division faculty have had more than 260 publications in peer-reviewed and other journals.

The gynecologic oncology research group at UC Irvine, led by Drs. Krishnansu Tewari and Leslie Randall, has an international reputation for its clinical research in gynecologic malignancies.

Clinical fellows in the division conduct both clinical and basic science investigation, integrating both aspects of pure science and medicine into the gynecologic oncology studies.

Research interests

Research interests are focused on the following areas:

  • Targeted therapy for gynecologic cancers, including ovarian, endometrial, and cervical cancers
  • Chemotherapy for gynecologic cancers
  • Cytoreductive surgery for advanced ovarian cancer
  • Heated intraoperative chemotherapy (HIPEC) for advanced ovarian cancer
  • Prognostic and predictive biomarkers in gynecologic cancers
  • Quality-of-life in cancer care
  • Palliative care for women with gynecologic cancers
  • Fertility-preserving therapy
  • Cancer in pregnancy
  • Advanced robotic surgery for gynecologic cancers
  • Human papillomavirus (HPV)-induced gynecologic infections
  • Drug resistance in gynecological cancer
  • Advanced oncology-based imaging and immuno-oncology clinical trials 

Contact us

If you would like more information about current or prospective clinical trials or studies, please contact:

Ashley Tydon 
Assistant Director, Clinical Trials Office